There are many people (maybe yourself included if you’re reading this article) who would prefer to use an iPod without having to use iTunes. Some run Linux as their operating system so iTunes is not an option. Others experience problems or interference with their iTunes from other programs on their computer. Still yet others just flat out don’t like iTunes.
No matter the reason, you have many choices. Depending on your operating system, you may have more choices than others.
A few of the more popular iTunes alternatives are Floola, WinAmp, gtkpod, Banshee, RhythmBox and Amarok. These are very popular and regularly updated options.
Most of these options are free or open-source, so you can just download each one and play around until you find the option that works best with your system.